Costimulation tolerance potentiates which of the following cytokine by following the costimulatory pathway?
Costimulation tolerance potentiates which of the following cytokine by following the costimulatory pathway? Correct Answer IL-2
Costimulation pathway influences the outcome of T‐cell stimulation and play a central role in immune tolerance. The definition of costimulatory pathways is not limited to the surface receptors that potentiate TCR signals, such as CD28 or inducible costimulator (ICOS), but also it also includes immunoregulatory receptors such as cytotoxic T‐lymphocyte antigen‐4 (CTLA‐4) and programed death‐1 (PD‐1), and most importantly the soluble factor IL‐2, which is intimately linked and has overlapping functions with some costimulatory receptors.