What changes take place in PTK (protein tyrosine kinase) on binding of CD4 to MHC?
What changes take place in PTK (protein tyrosine kinase) on binding of CD4 to MHC? Correct Answer It activates ZAP70 to become an active PTK
Activated protein tyrosine kinase helps in activating the T cells by receiving the signals from TCR (T cell receptor), CD4 or CD8. Specifically, CD4 and CD8 are associated with the cytoplasmic tyrosine kinase enzyme. This enzyme is also known as lymphocyte kinase (Lck). When CD4 binds to MHC, it allows Lck to phosphorylate and activate ZAP70 to become an active protein tyrosine kinase.