Lineage Commitment, Exit from Thymus and Final Maturation MCQ

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• T cells proliferate and differentiate into which of the following cells on receiving primary response?
  ক

  Effector T cells only

  খ

  Memory T cells only

  গ

  Effector and Memory T cells

  ঘ

  Helper, Effector and Memory T cells
• What changes take place in PTK (protein tyrosine kinase) on binding of CD4 to MHC?
  ক

  It activates CD45 

  খ

  It activates ZAP70 to become an active PTK

  গ

  It activates the phosphatase to become an active PTK

  ঘ

  It binds to CD45
• In what phase do the thymocytes enter the thymus?
  ক

  Double-positive markers

  খ

  Double-negative markers

  গ

  Single-positive markers

  ঘ

  In their original form
• Which of the following researcher studied the use of Rag2p-GFP in mice?
  ক

  John Stewart

  খ

  Fink

  গ

  Edward Jenner

  ঘ

  Pasteur
• The thymus provides an inductive environment for T lineage commitment at which of the following loci?
  ক

  Gamma-delta and alpha-beta TCR 

  খ

  Alpha-delta and gamma-delta TCR

  গ

  Alpha-gamma TCR 

  ঘ

  Alpha-beta TCR
• The lineage commitment of immature to mature T cells is mediated by which of the following receptor?
  ক

  BCR

  খ

  TCR

  গ

  APR

  ঘ

  APC and TCR
• Which of the following stage is NOT involved in T lymphopoiesis? 
  ক

  Double-negative cell stage

  খ

  Double-positive cell stage

  গ

  Single-negative cell stage

  ঘ

  Single-positive cell stage
• Lineage commitment is a process in which CD4–CD8– (double negative) thymocytes differentiate to CD4– and/or CD8– T cells. 
  ক

  True

  খ

  False
• Signals from TCR (T cell receptor) activate which of the following protein?
  ক

  Protein tyrosine kinase

  খ

  Cyclin dependent kinase

  গ

  Collagen

  ঘ

  Coronin and Elastin
• Which organ is responsible for production of diverse population of T cells?
  ক

  Thymus

  খ

  Bone marrow

  গ

  Liver

  ঘ

  Spleen