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Lineage commitment is a process in which CD4–CD8– (double negative) thymocytes differentiate to CD4– and/or CD8– T cells. 

Lineage commitment is a process in which CD4–CD8– (double negative) thymocytes differentiate to CD4– and/or CD8– T cells.  Correct Answer False

Lineage commitment is a very important developmental process which is subjected to the differentiation of CD4+CD8+ (i.e., double-positive) thymocytes into CD4+ and/or CD8+ T cells. There are various steps which lead to this differentiation process. The thymocytes are committed to differentiate and they do not change their fate. 

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