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At present, there are essentially two types of method of RNA structure prediction. One is the minimum free energy approach and the Second one is a comparative approach.

At present, there are essentially two types of method of RNA structure prediction. One is the minimum free energy approach and the Second one is a comparative approach. Correct Answer True

One is based on the calculation of the minimum free energy of the stable structure derived from a single RNA sequence. This can be considered an ab initio approach. The second is a comparative approach which infers structures based on an evolutionary comparison of multiple related RNA sequences.

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If the centroid structure is different from the minimum free-energy structure, the centroid structure is often closer to the phylogenetic prediction and contains fewer base pairs, or fewer false-positive base pair predictions, than the minimum free-energy prediction.
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