Bissoy.com
Doctors Medicines MCQs Q&A

One of the challenges in SWA is obtaining correct alignments in regions of low similarity between distantly related biological sequences.

One of the challenges in SWA is obtaining correct alignments in regions of low similarity between distantly related biological sequences. Correct Answer True

It is because mutations have added too much ‘noise’ over evolutionary time to allow for a meaningful comparison of those regions. Local alignment avoids such regions altogether and focuses on those with a positive score, i.e. those with an evolutionarily conserved signal of similarity.

Related Questions

If the two sequences share significant similarity, it is extremely ______ that the extensive similarity between the two sequences has been acquired randomly, meaning that the two sequences must have derived from a common evolutionary origin.
Which of the following statements(s) concerning natural regions of the world is/are correct? 1) Equatorial climatic regions have less urbanization 2) Mediterranean climatic regions have a high level of urbanization 3) Equatorial climatic regions have a high concentration of human population 4) Mediterranean climatic regions practice plantation farming Select the correct answer using the code given below:
Related sequences are identified through the database similarity searching and as the process generates multiple matching sequence pairs, it is often necessary to convert the numerous pair wise alignments into a single alignment.
If two organisms are distantly related and show no DNA homology there still may be similarity in their rRNA cistrons.
With reference to the process of obtaining information under the Right to Information (RTI) Act, which of the following statements is/are correct? A) There is no prescribed format of application for obtaining information. Applications can be made on plain paper. B) There is no need to tell what is the reason behind obtaining the information.
Progressive alignment methods use the dynamic programming method to build an MSA starting with the most related sequences and then progressively adding less related sequences or groups of sequences to the initial alignment.
The second step in FASTA is to narrow down the high similarity regions between the two sequences.
The main application of pairwise alignment is retrieving biological sequences in databases based on similarity.
Sequence similarity and sequence identity are synonymous for nucleotide sequences and protein sequences as well.
In EM algorithm, as an example, suppose that there are 10 DNA sequences having very little similarity with each other, each about 100 nucleotides long and thought to contain a binding site near the middle 20 residues, based on biochemical and genetic evidence. the following steps would be used by the EM algorithm to find the most probable location of the binding sites in each of the ______ sequences.