How many alternatively spliced transcripts are produced by factor VIII gene?
How many alternatively spliced transcripts are produced by factor VIII gene? Correct Answer Two
The factor VIII gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a non-covalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b.
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Feb 20, 2025