Myelofibrosis

A Is characterized by increased number of fibroblasts in the bone marrow
B Requires trephine biopsy for diagnosis
C Produces a low neutrophil alkaline phosphatase score
D Is usually accompanied by splenic atrophy
E Causes death most frequently by acute leukemic transformation

Correct Answer: Is characterized by increased number of fibroblasts in the bone marrow, Requires trephine biopsy for diagnosis, Produces a low neutrophil alkaline phosphatase score

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