Myeloproliferative disorders MCQ 6+

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• Myeloid metaplasia is associated with
  ক

  A variable peripheral white cell count

  খ

  Extramedullary haemopoiesis

  গ

  Anaemia

  ঘ

  The Philadelphia chromosome

  ঙ

  A decreased number of megakaryocytes in the marrow
• Features of myelofibrosis include
  ক

  Raised reticutocyte count

  খ

  Tear drop poikilocytosis

  গ

  Leuco-erythroblastic blood picture

  ঘ

  Giant platelet

  ঙ

  Hyper segmented neutrophil
• Myelofibrosis
  ক

  Is characterized by increased number of fibroblasts in the bone marrow

  খ

  Requires trephine biopsy for diagnosis

  গ

  Produces a low neutrophil alkaline phosphatase score

  ঘ

  Is usually accompanied by splenic atrophy

  ঙ

  Causes death most frequently by acute leukemic transformation
• Myeloproliferative disorders include
  ক

  Myelofibrosis

  খ

  Essential thrombocythaemia

  গ

  Polycythemia vera

  ঘ

  Myelodysplastic syndrome

  ঙ

  Chronic lymphocytic leukemia
• Features of polycythaemia rubra vera
  ক

  High haematocrit

  খ

  Neutophilic leucocytosis

  গ

  Presence of JAK-2 mutation

  ঘ

  High ESR

  ঙ

  Thrombocytopenia
• Isolated axillary lymphadenepathy is associated with
  ক

  Metastatic breast cancer

  খ

  Hand infection

  গ

  Chronic lymphocytic leukaemia

  ঘ

  Seminoma of testis

  ঙ

  EBV infection