Hematology MCQ 148+

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Patients with multiple myeloma frequently present with

ক
Bleeding

খ
Infection

গ
Uraemia

ঘ
Painful bones

ঙ
Peripheral neuropathy
Amyloidosis

ক
Can cause chronic renal failure

খ
Can cause nephrotic syndrome

গ
Can occur as a long term complication of dialysis

ঘ
Usually responds to immunosuppressive drug therapy

ঙ
Histologically can be seen after staining with Sudan black
Plasmapheresis is indicated in the following conditions

ক
Myasthenia Gravis

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RnD negative mother during pregnancy

গ
Guillain-Barre syndrome

ঘ
Rapidly progressing glomerulonephritis

ঙ
Incompatible blood transfusion
Components used for replacement of factor VIII in haemophilia include

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Cryoprecipitate

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Fresh frozen plasma

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Platelet concentrate

ঘ
Packed RBC

ঙ
Granulocyte concentrate
Cryoprecipitate indicated in

ক
Hemophila A

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Von-Willebrand disease

গ
Congenital fibrinogen deficiency

ঘ
Hemophilia B

ঙ
Antithrombin deficiency
142 Recognized features of Hypersplenism include-

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Erythroid hyperplasia

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Splenomegaly

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Pancytopenia

ঘ
Jaundice

ঙ
Megaloblastic anaemia
Splenectomy has a beneficial effect in

ক
Hereditary spherocytosis

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Idiopathic thrombocytopenic purpura (IT

গ
Thalassaemia major

ঘ
Sickle cell anaemia

ঙ
Hemoglobin H disease
Splenomegaly is present in

ক
Acute and chronic hemolysis

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Leishmaniasis

গ
Acute sepsis

ঘ
Acute intestinal obstruction

ঙ
Aplastic anemia
Features of hypersplenism are

ক
Anaema

খ
Thrombocytopenia

গ
Leukocytosis

ঘ
Prolonged clotting time

ঙ
Prolonged D-dimer
Feature/s of thrombotic thrombocytopenic purpura is/are

ক
Microagniopathic haemolytic anaemia

খ
Altered mental state

গ
Presence of high ADAMTS-13

ঘ
Raised serum creatinine

ঙ
Preceded by bacillary dysentery caused by E coli 0157:H7
The followings are the components of haemolytic Uraemic syndrome

ক
Uremia

খ
Hemolytic anemia

গ
Thrombocytopenia

ঘ
Heart failure

ঙ
Leucopenia
Haemolytic uremic syndrome is characterized by

ক
Microangiopathic haemolytic anaemia

খ
Azotemia

গ
Thrombocytopenic purpura

ঘ
Leukocytoclastic vasculitis

ঙ
Arthritis
Following statement(s) is (are) true regarding haemolytic uraemic syndrome (HUS)

ক
Antibiotics may paradoxically increase shiga toxin release

খ
Eculizumab blocks complement activities by cleavage of C5

গ
Plasma exchange significantly improve the outcome

ঘ
Microangiopathic hemolytic anaemia is a characteristic feature

ঙ
Rickettsial infection associated with diarrhoea associated (D+) HUS
Monoclonal gammopathy occurs in

ক
Multiple myeloma

খ
Leprosy

গ
Kala-azar

ঘ
Lymphoblastic

ঙ
Chronic active hepatitis
Features of antiphospholipid syndrome include

ক
Recurrent thrombosis

খ
Giant platelet

গ
Thrombocytosis

ঘ
Pregnancy losses in the third trimester of pregnancy

ঙ
Hypercellular bone marrow
Features of anti-phospholipid syndrome include

ক
Recurrent thrombosis

খ
Hypercoagulability

গ
Thrombocytosis

ঘ
Pregnancy losses in the third trimester of pregnancy

ঙ
Hypercellular bone marrow
Henoch Schonlein purpura in adults in characterized

ক
More frequent gut involvement

খ
More Common involvement of kidneys

গ
Relative parity of skin involvement

ঘ
A worse prognosis

ঙ
Involvement of the myocardium
Henoch-Schonlein Purpura

ক
Is a small vessel vasculitis

খ
Is characterized by presence of IgA deposition in biopsy from involved skin in direct

গ
Commonly lead to acute renal failure

ঘ
Is characterized by the presence of apthous ulcer

ঙ
Occurs mostly in adults
Henoch - Schonlein Purpura

ক
Typically presents in summer

খ
Always needs steroid

গ
Occurs mostly in adults

ঘ
Is a small vessel vasculitis

ঙ
Commonly involves buttocks
Immune thrombocytopenic purpura lTP is characterized by

ক
Splenomegaly

খ
Anaemia

গ
Shortened lifespan of platelets

ঘ
Increased level of anti-platelet antibodies

ঙ
Decreased megakaryocytes in the bone marrow
Treatments option for ITP includes

ক
Prednisolone

খ
Splenectomy

গ
Bone marrow transplantation

ঘ
Azathioprine

ঙ
Antithymocytic globulin
Low fibrinogen level is found in

ক
DIC (Disseminated intravascular Coagulatio

খ
Acute Liver disease

গ
Vitamin K deficiency

ঘ
Massive blood transfusion

ঙ
Heparin therapy
A 4 year old boy presents with prolonged bleeding. A complete blood count, Prothrombin time & activated thromboplastin time normal. The possibilities are

ক
Platelet function disorder

খ
Von- Willebrand disease

গ
Congenital factor VII deficiency

ঘ
Idiopathic thrombocytopenic purpura

ঙ
Hemophilia A
Prothrombin time is increased

ক
With warfarin therapy

খ
In fulminant hepatic failure

গ
Following splenectomy

ঘ
In haemolytic jaundice

ঙ
In haemophilia
Prothrombin time is increased in the following conditions

ক
Acute liver failure

খ
Obstructive jaundice

গ
Hemophilia

ঘ
Christmas disease

ঙ
Post-splenectomy
Bleeding time may be prolonged in

ক
ITP

খ
Von- Willebrands disease

গ
DIC

ঘ
Christmas disease

ঙ
Heamophilia
Prothrombin time and activated partial thromboplastin time both are prolonged in

ক
Acute liver failure

খ
Disseminated intravascular coagulation

গ
Low molecular weight heparin therapy

ঘ
Factor XIII deficiency

ঙ
Haemolytic uremic syndrome
Causes of prolonged prothrombin time are

ক
Treatment with oral anticoagulant drugs

খ
DIC

গ
Haemophilia A

ঘ
Deficiency of factor XI and XII

ঙ
Haemolytic disease of newborn
Prolonged APTT with normal PT is found in the following conditions

ক
Christmas disease

খ
Hemophilia A

গ
von Willibrandâs Disease

ঘ
Disseminated Intravascular Coagulation (DI

ঙ
Protein C deficiency
von Willebrand disease

ক
May cause menorrhagia

খ
May be treated with factor VIII concentrate

গ
May be treated with cryoprecipitate

ঘ
Is a cause of prolonged prothrombin time

ঙ
Is characterized by an increased restriction cofactor activity