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Adults: The usual dosage is 3000 mg daily, given in divided doses as follows:
- Two doses of two 750 mg tablets
- Two doses of three 500 mg tablets/capsules
- Three doses of two 500 mg tablets/capsules
Some patients, e.g., the elderly, may require a lower dosage to achieve therapeutic blood concentrations and to avoid the more common side effects such as auditory.
Alleviation of symptoms is gradual, and full benefit may not be evident for 3 to 4 days, when plasma salicylate levels have achieved steady state. There is no evidence for development of tissue tolerance (tachyphylaxis) but salicylate therapy may induce increased activity of metabolizing liver enzymes, causing a greater rate of salicyluric acid production and excretion, with a resultant increase in dosage requirement for maintenance of therapeutic serum salicylate levels.
Children: Dosage recommendations and indications for Salsalate use in children have not been established.
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