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Benign gastric and duodenal ulceration: 800 mg daily at bedtime or 400 mg bid for at least 4 wk (duodenal ulcer), 6 wk (gastric ulcer) and 8 wk (NSAID-associated ulcer). Maintenance: 400 mg daily at bedtime or bid. 

GERD: 400 mg 4 times/day or 800 mg bid for 42 wk. 

Zollinger-Ellison syndrome: 300 or 400 mg 4 times/day. 

Prophylaxis of GI haemorrhage from stress ulceration: 20000 mg 4 hrly. 

Prophylaxis of acid aspiration during general anaesth: 400 mg 9020 min before induction of anaesth up to 400 mg 4 hrly if needed. 

Non-ulcer dyspepsia: Max: 800 mg/day in divided doses. 

Prophylaxis of nocturnal heartburn: 100 mg at bedtime. 

Short bowel syndrome: Initial: 400 mg bid, adjusted according to response. 

Pancreatic insufficiency: 800600 mg/day in 4 divided doses. IV 

Benign gastric and duodenal ulceration; Zollinger-Ellison syndrome Intermittent infusion: 300 mg 6 hrly infused over 150 min. Max: 2400 mg/day. 

Continuous infusion: 37.5 mg/hr (900 mg/day). A 150 mg IV loading dose may be given in patients requiring rapid elevation of gastric pH.

Should be taken with food.

 

 

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