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Initial therapy: For patients with type 2 diabetes whose hyperglycemia can not be satisfactorily managed with diet and exercise alone: the recommended starting dose of combination is Glipizide 2.5 mg + Metformin 250 mg once daily with meal. In clinical trials of this combination as initial therapy, there was no experience, with total daily doses greater than Glipizide 10 mg + Metformin 2000 mg per day.
Second line therapy: For patients not adequately controlled on either glipizide or metformin alone, the recommended starting dose of this combination is Glipizide 2.5 mg + Metformin 500 mg or Glipizide 5 mg + Metformin 500 mg twice daily with the morning and evening meals. The daily dose should be titrated in increments of not more than Glipizide 5 mg + Metformin 500 mg up to the minimum effective dose to achieve adequate control of blood glucose or to a maximum dose of Glipizide 20 mg + Metformin 2000 mg per day.
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