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Adult:General Anesthesia-

  • IV Induction: 1.5 mg/kg single dose
  • IM Induction: 6.53mg
  • IV Infusion: 1mg/kg at 0.5mg/kg/min

Maintenance:

 The maintenance dose should be adjusted according to the patient's anesthetic needs and whether an additional anesthetic is employed. Increments of one-half to the full induction dose may be repeated as needed for maintenance of anesthesia.Rapid sequence Intubation, Induction - 2mg/kg IV

Pediatric:

General Anesthesia: 

  • IV Induction: 1 mg/kg IV; range: 43 mg/kg
  • IM Induction: 50 mg/kg; range: 0.5.5 mg/kg
  • Maintenance: 0.01.03 mg/kg/min continuous IV infusion

Maintenance:

 The maintenance dose should be adjusted according to the patient's anesthetic needs and whether an additional anesthetic is employed. Increments of one-half to the full induction dose may be repeated as needed for maintenance of anesthesia.

Rate of Administration: It is recommended that ketamine should be administered slowly (over a period of 60 seconds). More rapid administration may result in respiratory depression and enhanced pressor response.

The 100 mg/ml concentration of ketamine should not be injected intravenously without proper dilution. It is recommended the drug be diluted with an equal volume of either Sterile Water for Injection, USP, Normal Saline, or 5% Dextrose in Water.

Reconstitutions

To prepare a dilute solution containing 1 mg of ketamine per ml, aseptically transfer 10 ml (50 mg per ml vial) to 500 ml of Dextrose Injection, 5% or Sodium Chloride Injection, 0.9% and mix well. The resultant solution will contain 1 mg of ketamine per ml.

 

 

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