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Usual Adult Dosage

• For moderate to severe infection dose is 500 mg to 1 gm and frequency is every 6 to 8 hours

• For mild infections caused by Gram positive cocci dose is 250 mg to m00 mg and frequency is every 8 hours

• For acute uncomplicated urinary tract infection dose is 1 gm and frequency is every 12 hours

• For pneumococcal pneumonia dose is 500 gm and frequency is every 12 hours

• For severe life threatening infections dose is 1 gm to 1.5 gm and frequency is every 6 hours

Perioperative Prophylactic dose: To prevent postoperative infection, the recommended doses are: I. 1 gm IV or IM administered 1/2 hour to 1 hour prior to the start of surgery II . For lengthy surgery (e.g. 2 hours or more), 500 mg to 1 gm IV or IM during surgery III. 500 mg to 1 gm IV or IM every 6 to 8 hours for 24 hours postoperatively

Intramuscular Administration: Reconstitute vials with sterile Water for Injection. Shake well until dissolved. Cefazolin should be injected into a large muscle mass

Intravenous Administration: For direct injection reconstitution, dilute vials with approximately 10 ml Sterile Water for Injection for 500 mg and 1 gm. Inject the solution slowly over 3 to 5 minutes. For continuous infusion dilute reconstituted in 50 to 100 mL of one of the following solutions: 0.9% Sodium Chloride Injection,5% or 10% Dextrose Injection, 5% Dextrose and 0 .9% Sodium Chloride Injection.

Pediatric Dosage: In pediatric patients, a total daily dosage of 25 to 50 mg per kg of body weight, divided into 3 or 4 equal doses, is effective for most mild to moderately severe infections. Total daily dosage may be increased to 100 mg per kg of body weight for severe infections. Since safety of Cefazolin use in infants has not been established, it is not recommended

Probenecid may decrease renal tubular secretion of Cefazolin, when used concurrently, resulting in increased Cefazolin blood levels

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