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If the Nike backpack is made from nylon/polyester synthetic materials, then it should be fine to wash in the washing machine. First, read the label on the backpack to see whether it suggests washing instructions. Otherwise, it is recommended that you follow the instructions detailed above in Method 2 to wash the backpack. It’s a good idea to turn the bag inside out before washing (this protects the color and external features) and place it inside a pillowcase (added protection) before adding to the washing machine.

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