What do you do when your neighbors that live above you let their kids run and jump around from 6 pm until 12:30 am?

Most tenants are within their rights to any foot patterns you might hear above you. However, if you are experiencing those kind of issues after 10 pm, that's when it might be a problem you can complain about. Talk to your neighbour and see if they'd be willing to pay attention to how much noise the kids make since it's a disturbance to you. If that doesn't work, talk to your landlord. If that doesn't work, it might be necessary to take a legal approach. Decide if it's a noise complaint you'd like to pursue or if it's something you can ultimately deal with.