How long does it take to defrost 1.25 lb of turkey in the microwave?

The best way is to plan ahead and thaw it in the fridge the day prior. You can submerge the turkey, in its bag, changing the water every 30 minutes. This will take about 30 minutes per pound. It is quicker than the refrigerator, but requires more of your time. Keeping it under running water will reduce the time to defrost but will waste a lot of water. Not good, especially if you're in a drought area. Meat should not really be thawed in the microwave, but if you have no choice, you can use it; check your owner's manual for the minutes per pound and power level, and cook immediately after.