Is an original painting more valuable if it is published in prints?

It's tough to say. A work's value probably depends more on factors like quality, scale, intensity, and current market trends than whether an artist or publisher decides to make prints or even reprints. On the one hand, the prints might stoke excitement and help drive demand. On the other hand, prints mean more supply, which decreases valuation. If your original painting is from a well-established master, it probably doesn't affect the valuation. If your original painting is from a less well-known artist, it may hurt the value of your original.