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In enzymology, a hydroxyphenylpyruvate reductase is an enzyme that catalyzes the chemical reaction

Thus, the two substrates of this enzyme are 3-lactate and NAD, whereas its 3 products are 3-pyruvate, NADH, and H.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD or NADP as acceptor. The systematic name of this enzyme class is 4-hydroxyphenyllactate:NAD oxidoreductase. This enzyme is also called HPRP. This enzyme participates in tyrosine metabolism and phenylalanine metabolism.

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