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A glutamyl-tRNA reductase is an enzyme that catalyzes the chemical reaction

The 3 substrates of this enzyme are L-glutamate 1-semialdehyde, NADP, and tRNA, whereas its 3 products are L-glutamyl-tRNA, NADPH, and H.

This enzyme belongs to the family of oxidoreductases, to be specific, those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is L-glutamate-semialdehyde: NADP+ oxidoreductase. This enzyme participates in porphyrin and chlorophyll metabolism.

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