What is Glutamyl aminopeptidase?

Glutamyl aminopeptidase is an enzyme encoded by the ENPEP gene. Glutamyl aminopeptidase has also recently been designated CD249.

Glutamyl aminopeptidase is a zinc-dependent membrane-bound aminopeptidase that catalyzes the cleavage of glutamatic and aspartatic amino acid residues from the N-terminus of polypeptides. The enzyme degrades vasoconstricting angiotensin II into angiotensin III and therefore helps to regulate blood pressure.