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In enzymology, a hydrogen dehydrogenase is an enzyme that catalyzes the chemical reaction

Thus, the two substrates of this enzyme are H2 and NADP, whereas its two products are H and NADPH.

This enzyme belongs to the family of oxidoreductases, specifically those acting on hydrogen as donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is hydrogen:NADP+ oxidoreductase. Other names in common use include NADP+-linked hydrogenase, NADP+-reducing hydrogenase, hydrogen dehydrogenase , and simply hydrogenase.

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