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In enzymology, a malate dehydrogenase is an enzyme that catalyzes the chemical reaction

Thus, the two substrates of this enzyme are -malate and NADP, whereas its 3 products are oxaloacetate, NADPH, and H.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD or NADP as acceptor. The systematic name of this enzyme class is -malate:NADP oxidoreductase. Other names in common use include NADP-malic enzyme, NADP-malate dehydrogenase, malic dehydrogenase , malate NADP dehydrogenase, NADP malate dehydrogenase, NADP-linked malate dehydrogenase, and malate dehydrogenase. This enzyme participates in pyruvate metabolism and carbon fixation. This enzyme has at least one effector, hn.

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