1 Answers
In enzymology, a ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase is a bifunctional enzyme that catalyzes the chemical reaction
The 3 substrates of this enzyme are NAD and H2O, whereas its two products are ADP-ribose and nicotinamide. The reaction proceeds through cyclic ADP-ribose as intermediate, which is then hydrolyzed into ADP-ribose. This makes it different from NAD glycohydrolase , where the reaction does not proceed through cADPR.
This enzyme belongs to the family of hydrolases, specifically those glycosylases that hydrolyse N-glycosyl compounds. Other names of this enzyme in common use include nicotinamide adenine dinucleotide nucleosidase, triphosphopyridine nucleotidase, NAD nucleosidase, NADase, and nicotinamide adenine dinucleotide glycohydrolase. This enzyme participates in nicotinate and nicotinamide metabolism.