As is, you need a comma after "therefore" since it is an introductory phrase. But ask yourself which statement you're making is the cause and which is the effect. It seems that what you're saying is that children often find unusual solutions to things because they use their imagination more—which means "therefore" should introduce the second clause, not the first. Additionally, you have a comma splice. A correct sentence would be: "Children use their imagination more; therefore, they often find unusual solutions to things."

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