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I would suggest putting it in after you wash your hair, because then it has time to dry and it lets the serum do its job. I would be careful when putting it in your hair before using a hot tool, because it could fry your hair or ruin the hot tool. But if it helps, then use less than a quarter sized amount. I would also suggest that if you are putting serum in your hair while it is dry, you put it more towards the ends.

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