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Try an antihistamine cream to treat bedbug bites. Bed bugs aren't venomous and they don't carry diseases. Their bites are just like any other insect's, and you treat them the same way. Your body's defense system is having a histamine reaction to the numbing agents in the bedbugs' saliva, similar to a mosquito bite, so an antihistamine cream or calamine lotion would help. However, if you're having an ongoing issue with insect bites, you might ask a dermatologist to prescribe you a steroidal cream to apply to them.

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