Generic Name Cephradine
Bangla Name সেফরাডিন
Available brands 200
Language

Introduction

A semi-synthetic cephalosporin antibiotic.

Uses

Cefradine is a first-generation cephalosporin antibiotic used in the treatment of bacterial infections of the respiratory and urinary tracts and of the skin and soft tissues.

Associated Conditions

  • Bacterial Sepsis
  • Bloodstream Infections
  • Osteomyelitis
  • Peritonitis
  • Respiratory Tract Infections (RTI)
  • Septic Arthritis
  • Skin and Soft Tissue Infections
  • Urogenital infection bacterial

Mechanism of Action

Cefradine is a first generation cephalosporin antibiotic with a spectrum of activity similar to Cefalexin. Cefradine, like the penicillins, is a beta-lactam antibiotic. By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, it inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that Cefradine interferes with an autolysin inhibitor.

Route of Elimination

Over 90 percent of the drug is excreted unchanged in the urine within six hours.

Food Interactions

  • Take with or without food.

Dosage

For oral administration-
Adults:
  • Urinary tract infections: 500mg four times daily or 1g twice daily. Infections which are severe or chronic may necessitate the administration of higher doses. Where complications arise including prostatitis and epididymitis continued intensive treatment is required.
  • Respiratory tract infections: 250 to 500mg four times daily or 500mg to 1g twice daily, dependent on the site and severity of the infection.
  • Skin and soft tissue infections: 250 to 500mg four times daily or 500mg to 1g twice daily, again dependent on the site and severity of the infection.
Children:
  • Total daily dose of 25 to 50mg/kg given in two or four equally divided doses.
  • Otitis media: Total daily dose of 75 to 100mg/kg given in divided doses 6 to 12 hourly.
  • Maximum daily dosage: 4 gm
Elderly: The normal adult dose is appropriate. Patients with impaired renal or hepatic function should be monitored during treatment.

For injectable administration-
  • Adult: The usual dose is 2-4 gm daily in four equally divided doses up to 8 gm daily. For prophylaxis a single preoperative dose of 1-2 gm intramuscularly or intravenously is given.
  • Children: The dose is 50-100 mg/kg daily in four equally divided doses, up to 300 mg/kg daily in severe infection.

Frequently Asked Questions About Cephradine

1. What is Cephradine?

Cephradine is a first-generation cephalosporin antibiotic used to treat bacterial infections in humans.

2. What types of infections does Cephradine treat?

Cephradine is used to treat respiratory tract infections, skin infections, urinary tract infections (UTIs), and certain ear infections.

3. How does Cephradine work?

Cephradine works by inhibiting bacterial cell wall synthesis, leading to bacterial death.

4. Is Cephradine available over the counter?

No, Cephradine is a prescription antibiotic and must be prescribed by a doctor.

5. How should I take Cephradine?

Cephradine should be taken exactly as prescribed by your doctor, usually with or without food.

6. What is the typical dosage of Cephradine?

  • Adults: 250-500 mg every 6 hours, depending on the infection.
  • Children: Dosage is based on body weight and infection severity.

7. Can Cephradine be taken on an empty stomach?

Yes, but taking it with food may help reduce stomach upset.

8. What are the common side effects of Cephradine?

Common side effects include nausea, diarrhea, stomach pain, and mild skin rash.

9. Can pregnant women take Cephradine?

Cephradine is generally considered safe during pregnancy but should be used under medical supervision.

10. Can breastfeeding mothers take Cephradine?

Yes, but small amounts may pass into breast milk. Consult your doctor before use.

11. How long does it take for Cephradine to work?

Symptoms often improve within 48 hours, but the full course should be completed to prevent antibiotic resistance.

12. What should I do if I miss a dose?

Take the missed dose as soon as you remember, but skip it if it's almost time for your next dose. Do not double dose.

13. Can Cephradine be used for children?

Yes, but the dosage depends on the child’s weight and the severity of the infection.

14. What should I avoid while taking Cephradine?

Avoid alcohol and do not skip doses, as this can reduce the effectiveness of the antibiotic.

15. Can Cephradine treat viral infections like colds or flu?

No, Cephradine is only effective against bacterial infections.

16. Is Cephradine safe for people with kidney disease?

People with kidney disease may require a lower dose. Consult your doctor.

17. Can I drink alcohol while taking Cephradine?

It is best to avoid alcohol, as it may increase the risk of side effects like nausea and dizziness.

18. What happens if I take too much Cephradine?

Overdose symptoms may include nausea, vomiting, stomach pain, or seizures. Seek medical attention immediately.

19. Does Cephradine interact with other medications?

Yes, Cephradine may interact with blood thinners, diuretics, and other antibiotics. Inform your doctor about all medicines you are taking.

20. Can Cephradine be used for tooth infections?

Yes, Cephradine may be prescribed for bacterial tooth infections.

21. Can I take Cephradine for urinary tract infections (UTIs)?

Yes, Cephradine is commonly prescribed for UTIs.

22. Can Cephradine treat pneumonia?

Yes, Cephradine can be used to treat mild to moderate pneumonia.

23. Does Cephradine kill all bacteria?

No, it is effective against certain gram-positive and gram-negative bacteria.

24. Can Cephradine be used for ear infections?

Yes, it is sometimes prescribed for bacterial ear infections.

25. Does Cephradine cause diarrhea?

Yes, diarrhea is a possible side effect.

26. Is Cephradine a penicillin?

No, but it belongs to a related class of antibiotics called cephalosporins.

27. Can I take Cephradine with paracetamol?

Yes, Cephradine can be taken with paracetamol if needed for pain or fever.

28. Can Cephradine cause allergic reactions?

Yes, signs of an allergic reaction include rash, swelling, and difficulty breathing. Seek medical help if this occurs.

29. Does Cephradine make you sleepy?

Drowsiness is not a common side effect, but some people may feel fatigued.

30. Can I stop taking Cephradine if I feel better?

No, always complete the full course to prevent antibiotic resistance.

31. Can Cephradine treat skin infections?

Yes, it is used for bacterial skin infections.

32. Can Cephradine cause stomach pain?

Yes, mild stomach discomfort is a common side effect.

33. How should Cephradine be stored?

Store at room temperature, away from moisture and heat.

34. Does Cephradine cause yeast infections?

Yes, prolonged use may lead to yeast infections.

35. Can Cephradine cause headaches?

Headaches are a possible but uncommon side effect.

36. Can Cephradine be given intravenously?

No, Cephradine is usually taken orally or via injection.

37. Can Cephradine be used for food poisoning?

Only if caused by susceptible bacteria, not for viral food poisoning.

38. Can Cephradine be taken long-term?

No, it is meant for short-term use only.

39. Does Cephradine affect birth control pills?

It may reduce their effectiveness. Use additional contraception.

40. Can Cephradine cause dizziness?

Dizziness is an uncommon but possible side effect.

41. Is Cephradine safe for elderly patients?

Yes, but kidney function should be monitored.

42. Can Cephradine treat bronchitis?

Yes, it is sometimes prescribed for bacterial bronchitis.

43. Can Cephradine cause liver damage?

Rarely, but liver function should be monitored in long-term use.

44. Can Cephradine be used for gonorrhea?

No, other antibiotics like ceftriaxone are preferred.

45. Does Cephradine cause sun sensitivity?

Sun sensitivity is not a common side effect.

46. Can Cephradine treat typhoid fever?

No, other antibiotics like ciprofloxacin are preferred.

47. Can Cephradine cause weight loss?

Weight loss is not a common side effect.

48. Can I take Cephradine if I have diabetes?

Yes, but monitor blood sugar levels as some antibiotics may affect them.

49. Can Cephradine be used for sinus infections?

Yes, it is sometimes prescribed for bacterial sinus infections.

50. How long should I take Cephradine?

Take it for the full duration prescribed by your doctor.

Medical review

Last reviewed: 24 Jul 2026

Medically reviewed by:

This is general information, not personal medical advice. Consult a doctor before taking any medicine.

Taking medicines without doctor's advice can cause long-term problems.
Brand medicines containing Cephradine