Sinamin Syrup

Introduction

Sinamin Syrup 2 mg/5 ml is a first-generation antihistamine that has been used for the treatment of allergic rhinitis and urticaria. It is also an anti-inflammatory agent, used to help reduce congestion, sneezing, headaches, and other allergies caused by exposure to pollen and other allergens. It is a racemic mixture, containing equal amounts of both the (+) and (–) enantiomers.

Uses

Sinamin Syrup 2 mg/5 ml is used to provide relief from seasonal allergies such as hay fever, allergic conjunctivitis, and upper respiratory allergies. It is also used to relieve the itching and swelling of hives and other skin allergies. It may also be used to treat the symptoms of allergic rhinitis, such as sneezing, runny nose, and itchy eyes.

Brand Name	Sinamin
Type	Syrup
Weight	2 mg/5 ml
Generic	Chlorpheniramine Maleate
Manufacturer	Ibn Sina Pharmaceuticals Ltd.
Available in	English বাংলা

Mechanism of Action

Sinamin Syrup 2 mg/5 ml works by blocking the action of histamines, which are chemical messengers released during an allergic reaction. Histamines are responsible for the symptoms of allergic reactions, such as itching, sneezing, and swelling. By blocking their action, Sinamin Syrup 2 mg/5 ml helps to reduce these symptoms.

How Long Does it Take to Work?

Sinamin Syrup 2 mg/5 ml usually begins to work within 30 minutes of taking it. Maximum relief may not be experienced for up to 4 hours after taking the medication.

Absorption

Sinamin Syrup 2 mg/5 ml is rapidly and completely absorbed from the gastrointestinal (GI) tract after oral administration.

Route of Elimination

Sinamin Syrup 2 mg/5 ml is eliminated primarily in the urine, with a small amount excreted in the feces.

Dosage

Adult- Usual adult dose is 4 mg every 4-6 hours, maximum 24 mg daily.

Child-

6-12 years: 2 mg every 4-6 hours, maximum 12 mg daily.
2-5 years: 1 mg every 4-6 hours, maximum 6 mg daily.
1-2 years: 1 mg twice daily.

Below 1 year the use of Chlorpheniramine Maleate is not recommended. The adult dose of Sinamin Syrup 2 mg/5 ml for allergies is 4 mg taken twice daily. For hives, the adult dose is 4 mg taken 3 times daily. For children between 6-12 years old, the dose is 2 mg taken twice daily. For children younger than 6 years old, the dose should be determined by the healthcare provider.

Administration

Sinamin Syrup 2 mg/5 ml should be taken orally with or without food. Do not exceed the recommended dosage and do not take this medication for longer than recommended by your healthcare provider.

Side Effects

Common side effects of Sinamin Syrup 2 mg/5 ml include dry mouth, dizziness, drowsiness, nausea, vomiting, and headaches. Serious side effects may include difficult urination, blurred vision, confusion, tremors, and seizures.

Toxicity

In studies, Sinamin Syrup 2 mg/5 ml was found to have relatively low acute toxicity and high chronic toxicity. Chronic toxicity can cause fatal respiratory failure.

Precaution

Patients should not drive or operate heavy machinery while taking Sinamin Syrup 2 mg/5 ml due to the risk of drowsiness or dizziness. Alcohol should be avoided while taking this medication as it may intensify side effects. This medication should be taken with caution by patients with glaucoma, prostate problems, liver or kidney disease, or any other medical condition.

Interaction

Sinamin Syrup 2 mg/5 ml may interact with other medications. Patients should tell their healthcare provider about all the medications they are taking, including prescription, non-prescription, and herbal medications.

Disease Interaction

Patients with certain diseases, such as glaucoma, liver or kidney disease, and prostate problems, may be at increased risk for certain side effects when taking Sinamin Syrup 2 mg/5 ml.

Drug Interaction

Sinamin Syrup 2 mg/5 ml may interact with other drugs including: narcotics, sedatives, other antihistamines, muscle relaxants, and antispasmodics.

Food Interactions

Sinamin Syrup 2 mg/5 ml may interact with certain foods such as citrus fruits.

Pregnancy Use

Sinamin Syrup 2 mg/5 ml should not be used during pregnancy, unless recommended by a healthcare provider.

Lactation Use

Sinamin Syrup 2 mg/5 ml should not be used while breastfeeding, unless recommended by a healthcare provider.

Acute Overdose

An acute overdose of Sinamin Syrup 2 mg/5 ml can cause symptoms such as shallow breathing, drowsiness, confusion, and coma. Patients with an overdose of this medication should seek medical help immediately.

Contraindication

Sinamin Syrup 2 mg/5 ml is contraindicated in patients with a known hypersensitivity to it or its components.

Use Direction

Sinamin Syrup 2 mg/5 ml should be taken exactly as directed by your healthcare provider. Do not exceed the recommended dosage or take this medication for longer than recommended by your healthcare provider.