Roxiquin Tablet

Roxiquin Tablet 200 mg

Roxiquin Tablet 200 mg is an antimalarial drug used to treat certain types of parasites in the body. It is also used to prevent or treat certain autoimmune diseases, such as lupus and rheumatoid arthritis.

Uses for

Roxiquin Tablet 200 mg is used to treat or prevent malaria, a disease caused by parasites that can enter the body through the bite of a mosquito. It works by preventing or treating the growth of certain parasites within the body's cells.

It may also be used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus.

Brand Name	Roxiquin
Type	Tablet
Weight	200 mg
Generic	Hydroxychloroquine Sulphate
Manufacturer	Opsonin Pharma Ltd.
Available in	English বাংলা

Mechanism of Action

Roxiquin Tablet 200 mg works by suppressing the immune system, decreasing inflammation, and preventing the growth of certain parasites within the body’s cells. It is not known exactly how it works, but it is thought to interfere with communication between cells within the immune system.

How Long Does It Take to Work?

It typically takes up to three weeks for Roxiquin Tablet 200 mg to begin working. However, the full effect may take up to three months.

Absorption

Roxiquin Tablet 200 mg is rapidly and almost completely absorbed from the gastrointestinal tract.

Route of Elimination

The major route of elimination is by the kidney, with 70-80% of the administered dose excreted in the urine, and the remainder excreted in the feces.

Dosage

Hydroxychloroquine Sulphate tablets are for oral administration and are taken with food to avoid stomach upset.

Acute and chronic rheumatoid arthritis: 400 to 600 mg daily. When good response is obtained (usually 4 to 8 weeks), dose can be reduced to 50%.

Systemic Lupus Erythematosus (SLE): 400 mg once or twice daily for several weeks or months depending on response of the patients. Maintenance dose is 200 to 400 mg daily.

Malaria: In adults, an initial dose of 800 mg followed by 400 mg in 6-8 hours and 400 mg on each of two consecutive days. For children a total dose representing 25 mg/kg is administered in 3 days as follows.

First dose: 10 mg base/kg (but not exceeding a single dose of 620 mg base).
Second dose: 5 mg base/kg (but not exceeding a single dose of 310 mg base) 6 hours after first dose.
Third dose: 5 mg base/kg 18 hours after second dose.
Fourth dose: 5 mg base/kg 24 hours after third dose.

Dosage depends on the condition being treated, age, and weight of the patient. It is typically prescribed in either the tablet or liquid forms. Typical dosage for adults with malaria is 800 mg initially, followed by 400 mg 12 hours later, on the same day. The dosage for ongoing treatment is 400 mg daily for up to two weeks or more. The dosage for rheumatoid arthritis and lupus is 400-600 mg daily for three to four months.

Administration

Roxiquin Tablet 200 mg can be administered orally or intravenously (IV). It is recommended to take it with food to reduce the chance of stomach upset. Do not cut, crush, or chew the tablets.

Side Effect

The most common side effects of Roxiquin Tablet 200 mg include nausea, vomiting, stomach pain, diarrhea, dizziness, headache, loss of appetite, and rash. Other serious side effects may include vision changes, liver problems, and muscle weakness. Patients should contact their healthcare provider if they experience any of the above symptoms.

Toxicity

Roxiquin Tablet 200 mg is moderately toxic. Overdose may lead to life-threatening conditions, such as visual impairment, vomiting, nausea, confusion, muscle weakness, seizures, and coma. Seek immediate medical attention if a Roxiquin Tablet 200 mg overdose is suspected.

Precautions

Roxiquin Tablet 200 mg should be avoided by those with underlying kidney, liver, or heart disease, or by those with known allergies to the drug. It should not be used by pregnant or nursing women, or those planning to become pregnant, unless specifically instructed to by a doctor.

Interaction

It is important to tell your doctor of any other medications or supplements you are taking, as they may interact with Roxiquin Tablet 200 mg. This includes any over-the-counter medications, vitamins, or herbal supplements.

Disease Interaction

This medication should be used with caution in patients with a history of diabetes, lifestyle diseases (e.g., hypertension and obesity), autoimmune diseases (e.g., Crohn’s disease, rheumatoid arthritis, systemic lupus erythematosus), or those with a history of vision problems, seizures, psychiatric disorders, or liver or kidney disease.

Drug Interaction

There is a risk of potential drug interactions with Roxiquin Tablet 200 mg. Patients should inform their doctor if they are taking other medications, such as certain antibiotics (e.g., ciprofloxacin, norfloxacin, erythromycin), antifungal medications (e.g., ketoconazole, itraconazole), nonsteroidal anti-inflammatory drugs (e.g., ibuprofen), or some antidepressant medications (e.g., fluoxetine).

Food Interactions

Patients should avoid taking Roxiquin Tablet 200 mg with foods high in calcium, including dairy products, antacids, or calcium supplements, as this may reduce the absorption of the medication.

Pregnancy Use

Roxiquin Tablet 200 mg should not be used by pregnant women unless the potential benefit outweighs the risk to the unborn baby. Treatment should be stopped immediately if a woman becomes pregnant while taking this medication.

Lactation Use

It is not known if Roxiquin Tablet 200 mg is excreted into breast milk. Therefore, nursing mothers should discuss the risks and benefits with their doctor before taking this medication.

Acute Overdose

If an acute overdose is suspected, seek medical attention immediately. Symptoms of a Roxiquin Tablet 200 mg overdose may include nausea, vomiting, abdominal pain, loss of appetite, confusion, seizures, and coma.

Contraindication

Roxiquin Tablet 200 mg should not be used by those with known allergies to the drug, or by those with underlying kidney, liver, or heart disease. It should not be used in combination with other medications. It should also not be used by pregnant or nursing women.

Use Direction

Roxiquin Tablet 200 mg should be taken as directed by the healthcare provider. The dosage will depend on the condition being treated, the age and weight of the patient, and other factors.