Apetiz Tablet

Apetiz Tablet 160 mg

Megestrol acetate is a synthetic hormone used to treat certain types of cancer (most notably breast cancer) and certain types of anorexia (dysphagia) which can occur in people with AIDS. It is also used as a component of pet food as an appetite stimulant.

Uses for

Megestrol acetate is commonly used to treat breast cancer, endometrial cancer, prostate cancer, and certain kinds of anorexia (dysphagia) that occur with AIDS. It is also used for bregmatting and impregnation of sows as an appetite stimulant.

Brand Name	Apetiz
Type	Tablet
Weight	160 mg
Generic	Megestrol Acetate
Manufacturer	Aristopharma Ltd.
Available in	English বাংলা

Mechanism of Action

Megestrol acetate is a progestin hormone. It works by binding to progesterone receptors in the cells, thus causing estrogenic and anti-estrogenic effects. It also stimulates the appetite and helps restore normal appetite.

How long does it take to work?

The effects of megestrol acetate usually occur within a few days, but may take up to a few weeks. The improvement in appetite may occur within one to two weeks.

Absorption

Megestrol acetate is rapidly and completely absorbed from the gastrointestinal tract after oral administration.

Route of Elimination

Megestrol acetate is rapidly metabolized in the liver and excreted in the urine.

Dosage

Tablet:

Breast cancer: 160 mg/day
Endometrial carcinoma: 40-320 mg/day in divided doses.
At least 2 months of continuous treatment is considered an adequate period for determining the efficacy of Megestrol.

Oral Suspension: The recommended adult initial dosage of Megestrol Oral Suspension is 800 mg/day (20 ml/day).

Megestrol acetate is available in many forms with different doses, including 2.5, 5, 10, 20, 40, and 80 mg tablets, 10 mg/mL oral suspension, and 160mg/5mL suspension.

Administration

Megestrol acetate should be taken with food and should not exceed the recommended dose. It can be taken with or without food, but should always be taken with a full glass of water.

Side effects

Common side effects of Megestrol acetate include weight gain, nausea, vomiting, abdominal pain, headache, dizziness, fatigue, edema, decreased libido, and increased cholesterol levels. Rare side effects may include increased risk of blood clots, venous thrombosis, pulmonary embolism, and stroke.

Toxicity

The primary toxicity associated with Megestrol acetate is an increased risk of thromboembolic events such as blood clots. Other rare side effects may include inflammation of the liver, adrenal suppression, bone marrow suppression, and fluid retention.

Precautions

Patients taking Megestrol acetate should be monitored closely for signs of thromboembolic events, liver inflammation, and adrenal suppression. It should not be used during pregnancy or lactation, due to the risk of serious side effects. It may also interact with other medications and herbal supplements.

Interactions

Megestrol acetate may interact with other drugs, such as anticoagulants, corticosteroids, or oral contraceptives. It may also interact with certain herbal supplements and foods.

Disease interactions

Megestrol acetate should not be used in patients with clotting disorders, liver disease, kidney disease, or an adrenal disorder.

Drug interactions

Megestrol acetate may interact with other medications, including anticoagulants, corticosteroids, oral contraceptives, and certain herbal supplements. Taking Megestrol acetate with certain drugs can increase the risk of serious side effects.

Food interactions

Megestrol acetate should not be taken with grapefruit, orange, or apple juice. Taking Megestrol acetate with certain foods may reduce its effectiveness.

Pregnancy use

Megestrol acetate is not recommended for use during pregnancy, as there is a risk of serious side effects. It should also be used with caution in lactating mothers, as it may pass into the breast milk.

Lactation use

Megestrol acetate should be used with caution in lactating mothers, as it may pass into the breast milk. Women who are breastfeeding should not take megestrol acetate without consulting their doctor.

Acute overdose

Symptoms of an acute overdose with megestrol acetate include nausea, vomiting, increased blood pressure, and difficulty breathing. Treatment for an overdose consists of supportive care and close monitoring.

Contraindication

Megestrol acetate is contraindicated in patients with clotting disorders, liver disease, kidney disease, or an adrenal disorder.

Use direction

Megestrol acetate should be taken with food, and the tablets should not be broken or chewed. The dose and duration of treatment should be determined by the patient's doctor. The tablets should be taken at the same time each day and should not be taken with alcohol.

Storage condition

Megestrol acetate should be stored at room temperature, away from moisture and heat. It should not be exposed to light or temperatures above 86°F (30°C). The tablets should be kept in a tightly closed container and out of reach of children and pets.