What are the disadvantages of recombinant protein or polypeptide vaccines?

What are the disadvantages of recombinant protein or polypeptide vaccines? Correct Answer Cost, transportation, storage

The disadvantages of recombinant protein or polypeptide vaccines are: their cost is very high and often prohibitive since they are produced by either bacterial fermentation or in animal cell cultures. They have to be stored at low temperatures. This makes their storage and transportation problematic.
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Related Questions

Phytase, an enzyme produced by Aspergillus niger can be adsorbed on microcrystalline cellulose powder (MCCP). The adsorption follows a Langmuir isotherm and the maximum concentration of the protein that can be obtained on the adsorbent is 70 mg cm-1. At a concentration of 50 mg L-1 of protein in the solution, the concentration of protein on the adsorbent reaches 35 mg cm-1. It is desired to recover 90% of the protein from 1.5 liter of the cell free culture filtrate containing 220 mg L-1 protein by addition of MCCP to the solution. The concentration of the protein adsorbed on the solid at equilibrium will be:
A recombinant protein is to be expressed under the control of the lac promoter and operator in a strain of E. coli having the genotype lacI+ crp+. Even in the absence of inducer IPTG, low levels of expression of the recombinant protein are seen (leaky expression). Which one of the following should be done to minimize such leaky expression?
With reference to recent developments regarding ‘Recombinant Vector Vaccines’, consider the following statements : 1. Genetic engineering is applied in the development of these vaccines. 2. Bacteria and viruses are used as vectors. Which of the statements given above is/are correct? 
What is the importance of using Pneumococcal Conjugate Vaccines in India? 1. These vaccines are effective against pneumonia as well as meningitis and sepsis. 2. Dependence on antibiotics that are not effective against drug-resistant bacteria can be reduced. 3. These vaccines have no side effects and cause no allergic reactions. Select the correct answer using the code given below:
Read the passage and answer the questions that follow. Evaluation of candidate vaccines for COVID-19 should be done on technical parameters and programmatic suitability. An ideal vaccine would provide the following- immunity that is of a high degree (90%+ protective especially against severe illness), broad-scale (against different variants) and durable (at least five years if not lifelong); a vaccine that is safe (little or no side effects and definitely no serious adverse effects); a vaccine that is cheap (similar to current childhood vaccines); a vaccine that is programmatically suitable- single dose, can be kept at room temperature or at worst needs simple refrigeration between 2 degrees Celsius and 4 degrees Celsius, needle-free delivery, and a vaccine that is available in multi-dose vials, has long shelf life and is amenable to rapid production. Obviously, a vaccine having all these desirable characteristics is a pipe dream, and most vaccines fare well in some and not so well in other parameters, making it difficult to choose between them. What is the most appropriate meaning of the phrase PIPE DREAM?
Read the passage and answer the questions that follow. Evaluation of candidate vaccines for COVID-19 should be done on technical parameters and programmatic suitability. An ideal vaccine would provide the following- immunity that is of a high degree (90%+ protective especially against severe illness), broad-scale (against different variants) and durable (at least five years if not lifelong); a vaccine that is safe (little or no side effects and definitely no serious adverse effects); a vaccine that is cheap (similar to current childhood vaccines); a vaccine that is programmatically suitable- single dose, can be kept at room temperature or at worst needs simple refrigeration between 2 degrees Celsius and 4 degrees Celsius, needle-free delivery, and a vaccine that is available is multi-dose vials, has long shelf life and is amenable to rapid production. Obviously, a vaccine having all these desirable characteristics is a pipe dream, and most vaccines fare well in some and not so well in other parameters, making it difficult to choose between them. According to the passage, which of the following is NOT a desirable parameter for a vaccine?
Read the passage and answer the questions that follow. Evaluation of candidate vaccines for COVID-19 should be done on technical parameters and programmatic suitability. An ideal vaccine would provide the following- immunity that is of a high degree (90%+ protective especially against severe illness), broad-scale ( against different variants) and durable (at least five years if not lifelong); a vaccine that is safe (little or no side effects and definitely no serious adverse effects); a vaccine that is cheap (similar to current childhood vaccines); a vaccine that is programmatically suitable- single dose, can be kept at room temperature or at worst needs simple refrigeration between 2 degrees Celsius and 4 degrees Celsius, needle-free delivery, and a vaccine that is available in multi-dose vials, has long shelf life and is amenable to rapid production. Obviously, a vaccine having all these desirable characteristics is a pipe dream, and most vaccines fare well in some and not so well in other parameters, making it difficult to choose between them. What is the tone of the author in the passage?
Directions : In each of the following questions a statement is given, followed by two conclusions. Give answer :

Statements : About 50 per cent of the animal by-products - hair, skin, horns etc. is edible protein. American chemists have developed a method of isolating 45 per cent of this protein. They used an enzyme developed in Japan to break down soya protein.

Conclusions :
I. Americans have not been able to develop enzymes.
II. Animal by-products protein has the same composition as soya protein.
Protein engineering can be used to produce peptide and polypeptide vaccines, especially for protection against hazardous viruses.
A mutation in a gene that codes for a polypeptide results in a variant polypeptide that lacks the last three amino acids. What type of mutation is this?