Classification of Vaccines MCQ

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• __________ demonstrated a plasmid-induced immune response using mice by inoculating with a plasmid expressing human growth hormone which elicited antibodies instead of faltering growth.
  ক

  Stephen Johnston

  খ

  Karry Mullis

  গ

  Robert Hook

  ঘ

  Alexander Fleming
• Recombinant engineered vaccines are being extensively explored to eradicate the following factors, except _________
  ক

  Infectious diseases

  খ

  Cancers

  গ

  Allergies and cancers

  ঘ

  Mental illness
• A recombinant engineered vaccine is “direct manipulation of genes of weakened or killed pathogen for stimulating antibody production or cellular immunity against the pathogen but is incapable of causing severe infection”.
  ক

  True

  খ

  False
• The BCG vaccine was developed by ___________ and ____________
  ক

  Albert Calmette and Camille Guérin

  খ

  Marry Currie and Perry Currie

  গ

  Albert Einstein

  ঘ

  Robert Hook
• Who sets the rules for clinical trials?
  ক

  NHS- National Health Service

  খ

  NIH- National Institute of Health

  গ

  NDA- New Drug Administration

  ঘ

  FDA- Food and Drug Administration
• What is the key information required to develop a vaccine?
  ক

  Molecular pathogenicity of the disease

  খ

  Molecular pathogenicity of the disease-causing organism

  গ

  Unique immunologic response from the host

  ঘ

  Molecular pathogenicity of the disease and the disease-causing organism
• Which vaccine among these is used in its inactivated form?
  ক

  Influenza

  খ

  Measles

  গ

  Mumps

  ঘ

  Chickenpox
• Vaccines are used in all the forms, except _________
  ক

  Live-attenuated vaccines

  খ

  Inactivated vaccines

  গ

  Subunit, recombinant, polysaccharide, and conjugate vaccines

  ঘ

  Attenuated, inactivated, portions of protein, polysaccharides
• What causes smallpox?
  ক

  Bacteria

  খ

  Virus

  গ

  Fungi

  ঘ

  Protozoa
• Who developed the first vaccine?
  ক

  Pasteur

  খ

  Salk

  গ

  Jenner

  ঘ

  Landsteiner
• What are the disadvantages of recombinant protein or polypeptide vaccines?
  ক

  High cost and storage

  খ

  Storage and transportation

  গ

  Transportation and cost

  ঘ

  Cost, transportation, storage
• Which polypeptide of cholera enterotoxin is nontoxic but immunogenic?
  ক

  A1

  খ

  A2

  গ

  B

  ঘ

  B1
• Generally, the whole protein molecule is necessary for immunogenicity.
  ক

  True

  খ

  False
• The HPV protein-encoding genes are expressed in _______ vectors to create large amounts of protein.
  ক

  Bacteria

  খ

  Yeast

  গ

  Virus

  ঘ

  Protozoa
• Gardasil protects against which of the HPV types _________
  ক

  HPV- 6, 11, 16, 18

  খ

  HPV – 5, 6, 16, 18

  গ

  HPV – 1, 2, 5, 11

  ঘ

  HPV – 1, 2, 16, 18
• GARDASIL is an example of ____________
  ক

  DNA vaccines

  খ

  Recombinant vector vaccines

  গ

  Live vector vaccines

  ঘ

  RNA vaccines
• Virus proteins have been expressed in _______________
  ক

  Bacterial and yeast cells

  খ

  Yeast and mammalian cells

  গ

  Mammalian cells

  ঘ

  Mammalian, yeast and bacterial cells
• Who developed the Hepatitis B vaccine?
  ক

  Pasteur

  খ

  Salk

  গ

  Jenner

  ঘ

  Pablo DT Valenzuela
• The only recombinant vaccine that proved highly effective and is currently approved for human use is the vaccine against __________
  ক

  Rubella virus

  খ

  Poxvirus

  গ

  HPV infection

  ঘ

  Dengue virus
• DPT is a combination vaccination.
  ক

  True

  খ

  False