How the absolute surface area of hydrophobic drugs can be converted to their effective surface area?

How the absolute surface area of hydrophobic drugs can be converted to their effective surface area? Correct Answer Use of surfactant and hydrophilic diluents

Use of surfactant as a wetting agent decreases the interfacial tension and displaces the adsorbed air with the solvent and using hydrophilic diluents coat the surface and render them hydrophilic.
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