Drugs Absorption MCQ

Test your knowledge with important Drugs Absorption MCQ and their applications. These MCQs are beneficial for competitive exams too. Explore 30+ more Drugs Absorption MCQs on Bissoy. Bissoy App

• From the below options which will be the most widely used form of dosage?
  ক

  Emulsion

  খ

  Solutions

  গ

  Tablets

  ঘ

  Powders
• Viscous fluids and oils are administered in hard gelatin capsules.
  ক

  True

  খ

  False
• Hydrophobic drug with fine particle size in capsule results in a decreasing porosity of powder bed.
  ক

  True

  খ

  False
• Which option describes the function of the enteric coated drug?
  ক

  Tough dissolves slowly

  খ

  Thin dissolves completely

  গ

  Dissolves only in alkaline pH of the intestine

  ঘ

  Shellac coating
• Which coating is thin and dissolve rapidly?
  ক

  Sugar coating

  খ

  Film coating

  গ

  Enteric coating

  ঘ

  Sealing coating
• Which is the major rate-limiting step in the absorption of a drug from suspension dosage?
  ক

  Tablet disintegration to granules

  খ

  Granules disintegration to fine particles

  গ

  Fine particles dissolution

  ঘ

  Dissolution absorbed into the blood
• Why emulsion dosage form for lipophilic drugs proved better?
  ক

  Easy manufacturing

  খ

  The higher stability of the drug in emulsion form

  গ

  Presented a large surface area of oil to the GIT for the absorption of the drug

  ঘ

  Fast clearance from the plasma
• Which form of the drug has the highest bioavailability?
  ক

  Coated tablets

  খ

  Solutions

  গ

  Tablets

  ঘ

  Emulsions
• Aging of dosage form affects drug release.
  ক

  True

  খ

  False
• Which of the following will be the slowest step in tablet drug absorption?
  ক

  Tablet disintegration to granules

  খ

  Granules disintegration to fine particles

  গ

  Fine particles dissolution

  ঘ

  Dissolution absorbed into the blood
• What are the major stability problems which result in poor bioavailability of any orally administered drugs?
  ক

  Acidic degradation

  খ

  Degradation by salivary amylase

  গ

  Degradation of the drug in inactive form

  ঘ

  Interaction with the excipients and degradation in an inactive form
• Drug having a small partition coefficient can rapidly penetrate the lipid membrane but diffusion through the unstirred water layer is a rate-limiting step.
  ক

  True

  খ

  False
• What will be in the place of ‘?’ in the given picture?
  ক

  Plasma layer

  খ

  Aqueous unstirred diffusion layer

  গ

  Lipid membrane

  ঘ

  Blood vessel
• What could be the reason that irrespective of pH any drug gets absorbed mostly from the intestine?
  ক

  More surface area

  খ

  Long residence time

  গ

  Large surface area and long residence time

  ঘ

  Large surface area, long residence time, basic pH
• Acidic drugs are best absorbed through the stomach and basic drugs are best absorbed through the intestine.
  ক

  True

  খ

  False
• What helps the ionized drug molecules to pass through the cell membrane passively?
  ক

  Different pH

  খ

  Polar group

  গ

  Large lipophilic group

  ঘ

  Hydration
• According to the pH-partition theory which form of the drug gets absorbed mostly?
  ক

  Hydrated form

  খ

  Aggregated form

  গ

  Ionised

  ঘ

  Unionised
• A microclimate pH, different from the luminal pH exists at the membrane surface.
  ক

  True

  খ

  False
• Which one of these options is not one of the limitations of pH-partition theory?
  ক

  Presence if virtual membrane pH

  খ

  Absorption of ionized drugs

  গ

  Influence of GI surface area

  ঘ

  Dissolution rate
• Heroin with pKa 7.8 will be in which form in intestinal pH?
  ক

  Ionized form mostly

  খ

  Unionized form mostly

  গ

  Half ionized and half no ionized

  ঘ

  Will form aggregate
• All drugs which are weak acids or acidic in nature will be in a unionized form in the plasma.
  ক

  True

  খ

  False
• Nitrazepam a weak base, will be in which form in the stomach?
  ক

  Ionized form mostly

  খ

  Non-ionized form mostly

  গ

  Half ionized and half no ionized

  ঘ

  Will form aggregate
• Ibuprofen a weak acid, in the stomach will be present in which of the given form?
  ক

  Ionized form mostly

  খ

  Non-ionized form mostly

  গ

  Half ionized and half no ionized

  ঘ

  Will form aggregate
• What should be the range of oil/water partition coefficient of any drug?
  ক

  1-2

  খ

  3-4

  গ

  2-3

  ঘ

  1-3
• Example of a drug which has PKa > 11 is ________
  ক

  Cromolyn

  খ

  Imipramine

  গ

  Amitriptyline

  ঘ

  Mecamylamine
• Which one of these is not an example of a basic drug with pKa range 5-11?
  ক

  Cromolyn

  খ

  Imipramine

  গ

  Amitriptyline

  ঘ

  Chloroquine
• Which one of these is an example of a strong acid drug?
  ক

  Diazepam

  খ

  Ibuprofen

  গ

  Cromolyn

  ঘ

  Aspirin
• Acids in the pKa range 2.5-7.5 are greatly affected by changes in pH making their absorption pH dependent.
  ক

  True

  খ

  False
• What is the pH range of the intestine?
  ক

  4-5

  খ

  1-3

  গ

  1-8

  ঘ

  5-8
• What is the pH range of the stomach?
  ক

  1-4

  খ

  5-8

  গ

  1-3

  ঘ

  1-8