Factors Affecting Rate of Drug Dissolution MCQ

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• Larger the size of the counterion, greater the solubility.
  ক

  True

  খ

  False
• Which one of these is not an advantage of buffered aspirin tablets?
  ক

  Enhanced bioavailability

  খ

  Reduced gastric irritation

  গ

  Increased stability

  ঘ

  Increased ulcerogenic tendency
• What is pH?
  ক

  –ve log of H+ concentration

  খ

  +ve log of H+ concentration

  গ

  Log of H+ concentration

  ঘ

  H+ concentration
• Which one will be the easiest approach to enhance the solubility and dissolution of any drug?
  ক

  Micronize the drug

  খ

  Convert drug into their anhydrous form

  গ

  Convert drug into their hydrous form

  ঘ

  Convert drug into their salt form
• Which form of a drug has greater solubility?
  ক

  Anhydrous

  খ

  Hydrate

  গ

  Crystallised

  ঘ

  Monohydrate
• The solvate can exist in different crystalline forms called as _________
  ক

  Solvates

  খ

  Pseudopolymorphs

  গ

  Pseudopolymorphism

  ঘ

  Hydrate
• Which one of these is not an example of hydrophilic diluents?
  ক

  PVC

  খ

  Dextrose

  গ

  PVP

  ঘ

  PEG
• How the absolute surface area of hydrophobic drugs can be converted to their effective surface area?
  ক

  Use of surfactant

  খ

  Use of Hydrophobic diluents

  গ

  Use of surfactant and hydrophilic diluents

  ঘ

  No need of doing micronization
• In the case of hydrophobic drugs, micronization results in a decrease in effective surface area and thus fall is dissolution rate. Which of the below sentences cannot be a reason for the given statement?
  ক

  The hydrophobic surface of the drugs adsorbs onto their surface which inhibits their wettability

  খ

  The particles reaggregate to form larger particles due to their high surface free energy

  গ

  Extreme reduction in the particle size imparts surface charges that may prevent wetting

  ঘ

  Extreme reduction in the size brings the hydrophobic amino acids to the surface
• Absolute surface area is proportional to the dissolution rate of a drug.
  ক

  True

  খ

  False
• Particle size and surface area of a drug are directly related to each other.
  ক

  True

  খ

  False
• The total solid surface area of any particle is known as ___________
  ক

  Absolute surface area

  খ

  Effective surface area

  গ

  Total surface area

  ঘ

  Surface area
• For oral formulation, what should be the minimum aqueous solubility to avoid bioavailability problems?
  ক

  0.9%

  খ

  1%

  গ

  2%

  ঘ

  0.11%
• Which option will be the best example of the physicochemical properties of drugs?
  ক

  Solubility, particle size, polymorphism, salt form, pseudopolymorphism, complexation, wettability, pH, Pressure of disintegration

  খ

  Pressure of disintegration, polymorphism, salt form, pseudopolymorphism, complexation, wettability, pH

  গ

  Solubility, particle size, polymorphism, salt form

  ঘ

  Solubility, particle size, polymorphism, salt form, pseudopolymorphism, complexation, wettability
• Absorption of drugs can be categorized into 2 classes, physicochemical properties of drugs and Dosage form of the drug, on the basis of drug dissolution.
  ক

  True

  খ

  False