Mutations in which among the following gene is associated with the majority of cases of isolated ACTH deficiency in neonates?
Mutations in which among the following gene is associated with the majority of cases of isolated ACTH deficiency in neonates? Correct Answer TBX19
Mutations in TBX19 are associated with most cases of isolated neonate ACTH deficiency. This is the TPIT encoding gene, a transcription factor of the T-box which is only expressed in pituitary corticotrophs and melanotrophs.