Which domain mediate the High-affinity binding of a lipophilic ligand?

Which domain mediate the High-affinity binding of a lipophilic ligand? Correct Answer D and E

High-affinity binding of a lipophilic ligand is a shared characteristic of many nuclear receptors. This defining function of the receptor is mediated by the C-terminal ligand-binding domain (LBD), domains D and E.
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