In humans, which of the following types of Transplant Rejection is NOT mediated by MHC (HLA)?
In humans, which of the following types of Transplant Rejection is NOT mediated by MHC (HLA)? Correct Answer Acute Antibody Mediated Rejection
Acute Antibody Mediated Rejection (AMR) is NOT mediated by MHC (HLA). It occurs due to donor-specific antihuman leukocyte antigen antibodies. These antibodies activate the complement system and may develop before or after transplantation. On the other hand, Hyperacute Rejection occurs before or few minutes after transplantation whereas Acute Cellular Rejection occurs when recipient’s T-lymphocytes are activated by the donor tissue. Chronic rejection can occur over many years.
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Feb 20, 2025