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The formation of _____ is determined by ______ interactions, whereas the formation of ____ is strongly influenced by ______ interactions.

The formation of _____ is determined by ______ interactions, whereas the formation of ____ is strongly influenced by ______ interactions. Correct Answer α-helices, short-range, β-strands, long-range

Protein secondary structure prediction with high accuracy is not a trivial ask. It remained a very difficult problem for decades. This is because protein secondary structure elements are context dependent. The formation of α-helices is determined by short-range interactions, whereas the formation of β-strands is strongly influenced by long-range interactions. Prediction for long-range interactions is theoretically difficult. After more than three decades of effort, prediction accuracies have only been improved from about 50% to about 75%.

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