Which of the following is not a drawback of the progressive alignment method?
Which of the following is not a drawback of the progressive alignment method? Correct Answer In this method the use of affine gap penalties, long gaps is allowed, and, in some cases, this may limit the accuracy of the method
Another major limitation is the “greedy” nature of the algorithm: it depends on initial pair wise alignment. Once gaps introduced in the early steps of alignment, they are fixed. The final alignment could be far from optimal. The problem can be more glaring when dealing with divergent sequences.
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Feb 20, 2025