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The GCG alignment programs have a RANDOMIZATION option, which shuffles the second sequence and calculates similarity scores between the unshuffled sequence and each of the shuffled copies.

The GCG alignment programs have a RANDOMIZATION option, which shuffles the second sequence and calculates similarity scores between the unshuffled sequence and each of the shuffled copies. Correct Answer True

If the new similarity scores are significantly smaller than the real alignment score, the alignment is considered significant. This analysis is only useful for providing a rough approximation of the significance of an alignment score and can easily be misleading.

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