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The C-terminal domain of tyrosyl-tRNA synthetase contains major binding determinants for the tRNA.

The C-terminal domain of tyrosyl-tRNA synthetase contains major binding determinants for the tRNA. Correct Answer True

The above statement is true. The C-terminal domain of tyrosyl-tRNA synthetase contains major binding determinants for the tRNA. The C-terminal domain was excised at the level of the cloned gene and the kinetics of the N-terminal domain was assayed. The kinetics of the tyrosine activation were identical for the wild type and the truncated enzyme, but the truncated enzyme did not charge or bind tRNA.

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