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APC inactivates FVIIIa by proteolytic cleavage at which of the following sites?

APC inactivates FVIIIa by proteolytic cleavage at which of the following sites? Correct Answer R336 and/or R562

APC inactivates FVIIIa by proteolytic cleavage at R336 (A1 domain) and/or R562 (A2 domain). Amino acid substitutions at these positions have resulted in FVIII variants with increased hemostatic efficacy in in vitro and in vivo assays.

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Analysis of a hexapeptide using enzymatic cleavage reveals the following result:
• Amino acid composition of the peptide is: 2R, A, V, S, Y
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• Chymotrypsin digestion yields two fragments and the compositions are: (A, R, V, Y) and (R, S)
• Digestion with carboxypeptidase A yields no cleavage product.
Given: Trypsin cleaves at carboxyl side of R. Chymotrypsin cleaves at carboxyl side of Y. Carboxypeptidase A cleaves at amino side of the C-terminal amino acid (except R and K) of the peptide.
The correct amino acid sequence of the peptide is:
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