Substitutions of large hydrophobic residues in the protein cores with smaller amino acids have which of the following effect on the whole protein?

Substitutions of large hydrophobic residues in the protein cores with smaller amino acids have which of the following effect on the whole protein? Correct Answer Destabilizing effect

Substitutions of large hydrophobic residues in the protein cores with smaller amino acids have destabilizing effect on the whole protein. This happens probably because cavities are created within the protein structure.

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The signal sequences are typically _______ residues long, rich in _____ charged residues such as arginines as well as hydroxyl residues such as serines and threonines, but devoid of ______ charged residues.
Which of the following does not lead to exposure of hydrophobic amino acids on the surface of a protein?