The following statements about Mechanism of Action of Glucocorticoids are correct
A
Most mediator proteins are enzymes for metabolic actions
B
Act through intracellular receptors
C
Blocks vitamin D3 mediated induction of the osteocalcin gene
D
Increases transcription of genes for cycloxygenase-2 thus produces its anti-inflammatory effects
E
Decreases synthesis of annexin-1
F
which is important in negative feedback effect
Correct Answer: Most mediator proteins are enzymes for metabolic actions, Act through intracellular receptors, Blocks vitamin D3 mediated induction of the osteocalcin gene