Endocrine pharmacology MCQ 32+

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• Bromocriptine
  ক

  Is used in hyperprolactinemia

  খ

  Is a dopamin D2 receptor agonist

  গ

  Stimulates lactation

  ঘ

  Commonly causes diarrhoea

  ঙ

  Is effective in reducing symptoms of carcinoid syndrome
• Justify the statements
  ক

  Oxytocin is effective in last trimester but dinoprostone through out pregnancy

  খ

  Progesterone is a natural tocolytic

  গ

  Mg SO4 is an ecbolic

  ঘ

  Ergometrine is indicated in the first stage of labour

  ঙ

  Bromocriptine causes hyperprolactinaemia
• The uterine myometrium at term is contracted by
  ক

  Oxytocin

  খ

  Prostaglandin

  গ

  Progesterone

  ঘ

  Halothane

  ঙ

  Nitrous oxide
• In infertile women following drugs are used to stimulate ovulation
  ক

  Clomiphene

  খ

  FSH (Follicle stimulating hormon

  গ

  Ethinyl oestradiol

  ঘ

  Bromocriptine

  ঙ

  Dihydroeandrosterone
• Drugs that induces ovulation are
  ক

  Clomiphene

  খ

  Human chorionic gonadotropin

  গ

  Bromocriptine

  ঘ

  Follicle stimulating hormone

  ঙ

  Ethinyl oestradiol
• Ovulation in infertile women is stimulated by
  ক

  Clomiphene

  খ

  FSH

  গ

  Norethisterone enanthate

  ঘ

  Bromocriptin

  ঙ

  Prolactine
• Drugs used to stimulate ovulation in infertile women are
  ক

  Clomiphene

  খ

  Follicle stimulating hormone (FS

  গ

  Gonadotropin releasing hormone (GnR

  ঘ

  Ethinyl oestradiol

  ঙ

  Bromocriptine
• Women taking combined oral contraceptive pills will have higher risk of
  ক

  Breast cancer

  খ

  Cervical cancer

  গ

  Gall bladder disease

  ঘ

  Ovarian carcinoma

  ঙ

  Endometrial carcinoma
• Combined oral contraceptive pills
  ক

  Act by stopping ovulation

  খ

  Is contraindicated in breast cancer

  গ

  Act by disrupting existing pregnancy

  ঘ

  Act by making cervical mucus thin

  ঙ

  Give protection against STD
• Contraceptives contain hormone as an ingredient are
  ক

  Mini pill

  খ

  Oral contraceptives

  গ

  Emergency contraceptives

  ঘ

  Cu T 380A

  ঙ

  Lippes loop
• The progesterone only pill
  ক

  Is Liable to cause amenorrhea

  খ

  Is safe and effective in lactating women

  গ

  Can be prescribed to a women with a medical history of venous thromboembolic episode

  ঘ

  Acts to suppress the adenohypophysis

  ঙ

  Increases tubal motility
• Adverse effects of oral prednisolone are
  ক

  Hypertension

  খ

  Diabetes mellitus

  গ

  Cataract

  ঘ

  Hypogonadism

  ঙ

  Skin rash
• The following statements about Mechanism of Action of Glucocorticoids are correct
  ক

  Most mediator proteins are enzymes for metabolic actions

  খ

  Act through intracellular receptors

  গ

  Blocks vitamin D3 mediated induction of the osteocalcin gene

  ঘ

  Increases transcription of genes for cycloxygenase-2 thus produces its anti-inflammatory effects

  ঙ

  Decreases synthesis of annexin-1

  চ

  which is important in negative feedback effect
• Glucocorticoids are useful in the treatment of
  ক

  Ulcerative colitis

  খ

  Acute leukaemia in children

  গ

  Peptic ulcer

  ঘ

  Psychosis

  ঙ

  Cushing's disease
• Glucocorticoids
  ক

  Are anti-inflammatory drugs

  খ

  Produce peptic ulcer

  গ

  Are essential for treatment of Addison’s disease

  ঘ

  Are effective in the treatment of bronchial asthma

  ঙ

  Produce effect by binding to receptors on the cell membrane
• Glucocorticoids having high anti-inflammatory action are
  ক

  Dexamethasone

  খ

  Prednisolone

  গ

  Hydrocortisone

  ঘ

  Beclomethasone

  ঙ

  Prednisone
• Adverse effects of metformin are
  ক

  Lactic acidosis

  খ

  Abdominal discomfort

  গ

  Diarrhoea

  ঘ

  Weight gain

  ঙ

  Hypoglycamia
• The beneficial effects of metformin are:
  ক

  Reduction hepatic glucose production

  খ

  Rarely hypoglycaemia or weight gain

  গ

  Increasing the number of insulin receptors

  ঘ

  Used in combination with sulfonylurea

  ঙ

  Stimulation insulin secretion
• Sulfonylureas
  ক

  Increase the secretion of insulin by β-cells

  খ

  Decrease serum glucagon

  গ

  Exhibit high affinity for plasma protein binding 99%

  ঘ

  Decrease the number of insulin receptors

  ঙ

  Can be used in renal disease
• Statement about hypoglycaemic agents include:
  ক

  Glipizide produces less hypoglycemia compared to Glibenclamide

  খ

  Pioglitazone may provoke cardiac congestion

  গ

  Metformin increases hepatic glucose out put

  ঘ

  Repaglinide is euglycemic

  ঙ

  Insulin glargine is shorter

  চ

  acting than isophane insulin
• The following statements about Pharmacotherapy of Diabetes Mellitus are correct:
  ক

  Insulin therapy is always associated with some degree of hypoglycaemia.

  খ

  Resistance against human Insulin is best treated by changing to bovine insulin.

  গ

  Pregnant diabetic patients are best treated by Biguanides because they are not teratogenic.

  ঘ

  Human insulin best therapeutically because of lesser chance of hypoglycaemia.

  ঙ

  α-glucosidase-inhibitor therapy is equally effective as Sulphonylurea drug in NIDDM.
• Euglycaemic anti-diabetic drugs are
  ক

  Metformin

  খ

  Pioglitazone

  গ

  Glipizide

  ঘ

  Tolazamide

  ঙ

  Glyburide
• Linagliptin
  ক

  Lowers blood glucose in type ii diabetes

  খ

  Causes hypoglycemia

  গ

  Is contraindicated in renal failure

  ঘ

  Is a GLP analogue

  ঙ

  Is an incretin like hormone
• Side-effects of insulin therapy are
  ক

  Hypoglycemia

  খ

  Weight gain

  গ

  Hypertension

  ঘ

  Hyperkalemia

  ঙ

  Chronic renal failure
• Drugs causing hyperglycaemia are
  ক

  Thiazides

  খ

  Diazoxide

  গ

  Theophylline

  ঘ

  Nitroglycerine

  ঙ

  Prazosine
• Anti-diabetic drugs reducing body weight are
  ক

  SGLT-2 inhibitors

  খ

  GLP-1 analogues

  গ

  Thiazolidinediones

  ঘ

  Metformin

  ঙ

  DPP-4 inhibitors
• Metformin causes
  ক

  Gastrointestinal upset

  খ

  Lactic acidosis

  গ

  Hypoglycemia

  ঘ

  Impaired kidney function

  ঙ

  Weight gain
• Drugs causing hypothyroidism are
  ক

  Lithium

  খ

  Amiodarone

  গ

  Iodopaque

  ঘ

  Digoxin.

  ঙ

  Thalidomide