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A patient was brought to the emergency department after a head injury. The nurse noticed that there is clear drainage from the nose. Which of the following test is useful and most reliable to determine if the drainage is a cerebrospinal fluid (CSF)?

A patient was brought to the emergency department after a head injury. The nurse noticed that there is clear drainage from the nose. Which of the following test is useful and most reliable to determine if the drainage is a cerebrospinal fluid (CSF)? Correct Answer <span style="color: rgb(34, 34, 34); ">Test for Beta2-transferrin </span>

Explanation:-

  • Testing Successfully Employed in the Diagnosis of Skull-Based CSF Leaks The beta-2-transferrin test is a highly sensitive and specific test for the presence of CSF in body fluids.
  • Test for beta 2-transferrin is the most reliable test to determine whether the nasal drainage is CSF because the substance is only present in CSF.
  • The CSF contains a large amount of glucose. A rapid but highly unreliable test is the glucose-content determination with the use of glucose oxidase per paper.
  • This method of detecting cerebrospinal fluid (CSF) rhinorrhea is no longer reliable a screening or confirmatory test to detect the presence of CSF in the nasal cavity because the presence of reducing substance present in the lacrimal-gland secretions can lead to false-positive results.

Additional Information

  • The volume of CSF, estimated to be approximately 150 ml in adults, is distributed between 125 ml in the subarachnoid spaces of the cranial and spinal cord and 25 ml in the ventricles.
  • Cerebrospinal fluid (CSF) is a clear, colorless, and transparent fluid that surrounds the brain and spinal cord of all vertebrates.
  • It circulates through the cavity of the brain, subarachnoid space, and central canal of the spinal cord.

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