A newborn is presented with a bloated abdomen shortly after birth with passing of less meconium. A full thickness biopsy of the rectum was carried out. Which one of the following rectal biopsy findings is most likely to be present?

A newborn is presented with a bloated abdomen shortly after birth with passing of less meconium. A full thickness biopsy of the rectum was carried out. Which one of the following rectal biopsy findings is most likely to be present? Correct Answer Lack of ganglion cells

Concept-

  • The failure of passing meconium in first 24 hours may be a sign of medical condition such as intestinal obstruction.
  • The baby passes stool the meconium is passes out of their body

Stimulate the baby to bowel’s by doing the following:

  • Bend their knees towards their chest.
  • Gently massage their abdomen.
  • Give him warm bath for relax muscles.

Explanation-

  • The absence of ganglion cell leaves the affected portion of intestine paralyzed and unable to propagate stool.
  • Hirschsprung disease is a birth defect. This disorder is characterized by the absence of ganglion cell
  • The absence of ganglion cell causes the muscles in the bowel to lose their ability to move stool through intestine.

Additional Information

  • Muscular propria thickened – thickened muscular propria was define as being present when width of muscular interna and externa of small intestine.
  • Hyalinisation of muscular coat -  a condition in which normal tissue deteriorates into a homogenous translucent material.
  • Fibrosis of submucosa – fibrosis submucosa characterized by abnormal collagen deposition.it is precancerous disorder and transform into malignant

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Thickness of 8 tyres L, M, N, O, P, Q, R and S is compared. Thickness of no two tyres is same. Thickness of N is more than L but less than 6 tyres. Thickness of O is more than M but less than Q. Thickness of P is less than only two tyres. Thickness of Q is not more than P. Which of the following statement is not correct?